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PROMOGRAN™ Plus Matrix

Products described on this website (and associated product information), may not be available for sale in all markets as a result of local regulatory requirements. For information regarding product availability in your market, please contact your local Acelity/KCI representative here.

A Clinically Proven Combination

PROMOGRAN™ Plus Matrix is comprised of a sterile, freeze dried composite of 44% oxidized regenerated cellulose (ORC), 55% collagen and 1% silver-ORC. Silver-ORC contains 25% w/w ionically bound silver, a well-known antimicrobial agent.

Optimum wound environment
PROMOGRAN™ Plus Matrix maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelization and optimal wound healing. 
What is the role of silver in PROMOGRAN™ Plus Matrix? The dressing contains ionically bound silver, a well-known antimicrobial agent1

Specific indications, contraindications, warnings, precautions and safety information exist for KCI products and therapies. Healthcare providers should review the product User Manual, Safety Information and/or Instructions for Use prior to application.


  • Overview
  • How it Works
  • Indications & Applications
  • Evidence & Outcomes
  • Ordering

Overview

Easy to Use Reduction in Wounds Displaying Signs of Infection



In a 14-week RCT comparing PROMOGRAN™ Plus Matrix (n=25), with Control (n= 15), the number of patients withdrawn from the study due to infection was Significantly greater in the control group 0% VS. 31% (p=0.012)1 (n=40) 

79% VS. 43% For the standard of care (Improved defined as >50% reduction in wound size)1 

Collagen-14-week-study.png

Control-Bacteria-Growth.png

 

How it Works

  • OVERVIEW
  • SPECIFICATIONS

Maintains an optimum wound-healing environment 

In the presence of exudate, PROMOGRAN™ Plus Matrix transforms into a soft, conformable, biodegradable gel, allowing contact with all areas of the wound. 

PROMOGRAN™ Plus Matrix maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelialization and optimal wound healing.

  • Optimum wound environment
  • Clinically proven  

 

PROMOGRAN-PLUS-HDW-940x740.png
Product description 
 
PROMOGRAN™ Plus Matrix is comprised of a sterile, freeze dried composite of 44% oxidized regenerated cellulose (ORC), 55% collagen and 1% silver-ORC. Silver-ORC contains 25% w/w ionically bound silver, a well-known antimicrobial agent. In the presence of exudate, the PROMOGRAN™ Plus Matrix transforms into a soft, conformable, biodegradable gel, and thus allows contact with all areas of the wound.

PROMOGRAN™ Plus Matrix, when covered with a semi-occlusive dressing, maintains a physiologically moist microenvironment at the wound surface. This environment is conducive to granulation tissue formation, epithelialization and optimal wound healing.

PROMOGRAN™ Plus Matrix provides an effective antibacterial barrier as demonstrated by the in-vitro reduction of bacterial growth with common wound pathogens such as, Pseudomonas aeruginosa, Staphylococcus aureus, Eschericia coli and Streptococcus pyogenes. Reduction of bacterial bioburden in the dressing may result in reduced risk of infection. Literature reports of in-vitro testing indicate that collagen fibers provide a biodegradable matrix for cellular invasion and capillary growth. In laboratory testing, Collagen-ORC has been shown to absorb components of wound exudate.

Indications & Applications

  • INDICATIONS
Specific indications, contraindications, warnings, precautions and safety information exist for KCI products and therapies. Healthcare providers should review the product User Manual, Safety Information and/or Instructions for Use prior to application.

PROMOGRAN™ Plus Matrix is indicated for the management of wounds healing by secondary intent which are clear of necrotic tissue including:

 

  • Diabetic ulcers
  • Venous ulcers
  • Pressure ulcers
  • Ulcers caused by mixed vascular aetiologies
  • Traumatic and surgical wounds


PROMOGRAN™ Plus Matrix is a primary dressing that can be cut to fit the wound with scissors and must be covered with either gauze, a non-adhering or a hydropolymer dressing in order to maintain a moist wound healing environment.

Storage
PROMOGRAN™ Plus Matrix should be stored away from direct light. Over-exposure to light may cause some discolouration, however this does not affect dressing usage. Store below 25 °CI 77 °F. Prepare wound bed per your standard wound care protocol and debride when necessary. For optimal effect, apply PROMOGRAN™ Plus Matrix directly to the whole wound bed.

  • For a wound with low or no exudate apply PROMOGRAN™ PLUS Matrix and hydrate with saline or Ringer's solution. This will initiate the gel forming process.
  • After hydration PROMOGRAN™ Plus Matrix will intimately contact the wound.
  • The biodegradable gel is naturally absorbed over time.

PROMOGRAN™ Plus Matrix must be covered with either gauze, a non-adhering or a hydropolymer dressing in order to maintain a moist wound healing environment. 

After initial treatment, re-treat the wound with PROMOGRAN™ Plus Matrix up to every 72 hours depending upon the amount of exudate. It is not necessary to remove any residual PROMOGRAN™ Plus Matrix. For heavily exuding or infected wounds it may be necessary to retreat the wound with PROMOGRAN ™ Plus Matrix every 24 hours. 

Evidence & Outcomes

The efficacy of PROMOGRAN™ Plus Matrix is supported by clinical evidence, including a published RCT. Acelity Clinical Evidence is a resource for healthcare professionals to explore preclinical, clinical, and review articles discussing the use of Acelity™ products. 

 

Clinical Evidence

Additional summary of evidence and outcomes.
TITLE Collagen-based wound dressings for the treatment of diabetes-related foot ulcers: a systematic review
View Abstract on PubMed
STUDY TYPE All levels
DATE 2013
AUTHORS Holmes, et al.
TITLE Prospective and randomised evaluation of the protease-modulating effect of oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers.International Wound Journal. 2015 May 23
View Abstract on PubMed
STUDY TYPE All levels
DATE 2015
AUTHORS Kloeters O, et al. 
TITLE A randomized controlled trial on collagen/oxidized regenerated cellulose / silver vs best standard of care.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2013
AUTHORS Gottrup, et al.
TITLE A retrospective study of sequential therapy with advanced wound care products versus saline gauze dressings: Comparing healing and cost.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2010
AUTHORS Snyder, et al.
TITLE An in vitro model to evaluate the ability of collagen/ORC/silver to absorb components of wound exudate and reduce inflammatory protease activity compared with other dressings.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2011
AUTHORS Gibson M, et al.
TITLE Can natural materials be adapted to optimize their efficiency in wound care?
View Abstract on PubMed
STUDY TYPE All levels
DATE 2014
AUTHORS Gibson M, et al.
TITLE Clinical experiences derived from implementation of an easy to use concept for treatment of wound healing by secondary intention and guidance in selection of appropriate dressings
View Abstract on PubMed
STUDY TYPE All levels
DATE 2011
AUTHORS Braumann, et al.
TITLE Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. Cirugia Espanola. 2007 Jul;82(1):27-31.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2007
AUTHORS Lazaro-Martinez JL, et al.
TITLE A pilot randomised trial to determine the effects of a new active dressing on wound healing of venous leg ulcers
View Abstract on PubMed
STUDY TYPE All levels
DATE 2008
AUTHORS Lanzara, et al.
TITLE Effect of oxidized regenerated cellulose/collagen matrix on proteases in wound exudate of patients with diabetic foot ulcers. Journal of Wound, Ostomy, and Continence Nursing. 2011 Sep-Oct;38(5):522-8.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2011
AUTHORS Ulrich D, et al.
TITLE A retrospective study of sequential therapy with advanced wound care products versus saline gauze dressings: comparing healing and cost
View Abstract on PubMed
STUDY TYPE All levels
DATE 2010
AUTHORS Snyder, et al.
TITLE Managing the wound environment using collagen/ORC/ silver dressing
View Abstract on PubMed
STUDY TYPE All levels
DATE 2010
AUTHORS Cullen B, et al.
TITLE The benefits of oxidised regeneratThe ed cellulose for wound healing. Presented at wound UK harrogate 2011, November 14-16, 2011, Harrogate, UK
View Abstract on PubMed
STUDY TYPE All levels
DATE 2011
AUTHORS Cullen B, et al.
TITLE Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration. International Wound Journal. 2008 Jun;5(2):195-203.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2008
AUTHORS Smeets, et al.
TITLE In vitro and clinical data demonstrating the ability of collagen/PRD/silver to overcome the hostile chronic wound environment.
View Abstract on PubMed
STUDY TYPE All levels
DATE 2010
AUTHORS Cullen B, et al.
TITLE THE ROLE OF PROMOGRAN IN REBALANCING THE WOUND ENVIRONMENT AND ITS EFFECT ON HEALING: 547. Shock, 2004
View Abstract on PubMed
STUDY TYPE All levels
DATE 2004
AUTHORS Cullen B, et al.
TITLE Modulation of the chronic wound environment; an in vitro evaluation of advanced wound therapies. Presented at the Symposium on Advanced Wound Care, April 28-May 1, 2007, Tampa, FL
View Abstract on PubMed
STUDY TYPE All levels
DATE 2007
AUTHORS Cullen B, et al.
TITLE Expression of matrix-metalloproteases in the fluid of chronic diabetic foot wounds treated with a protease absorbent dressing. Experimental and Clinical Endocrinology and Diabetes. 2011 May;119(5):286-90. Epub 2010 Oct 28
View Abstract on PubMed
STUDY TYPE All levels
DATE 2012
AUTHORS Motzkau M, et al.
TITLE The role of oxidised regenerated cellulose/collagen in wound repair: effects in vitro on fibroblast biology and in vivo in a model of compromised healing. International Journal of Biochemistry and Cell Biology. 2002 Dec 1;34(12):1557-1570
View Abstract on PubMed
STUDY TYPE All levels
DATE 2002
AUTHORS Hart J, et al.

Ordering


To order any of the products listed below, please contact your KCI representative or call your local KCI Office. Click here to view our locations.
  • PROMOGRAN™ Plus Matrix
    PRODUCT PRODUCT CODE   ORDERING OPTION
     
    FS-380x380-promogran-prisma-packs.jpg

    PROMOGRAN™ Plus Matrix

    28 cm2

     
           
    MA028  5
     
    FS-380x380-promogran-prisma-packs.jpg

    PROMOGRAN™ Plus Matrix

    123 cm2

     
     
    MA123  5
     
    FS-380x380-promogran-prisma-packs.jpg

    PROMOGRAN™ Plus Matrix

    28 cm2

     
     
    MA028  10
     
    FS-380x380-promogran-prisma-packs.jpg

    PROMOGRAN™ Plus Matrix

    123 cm2

     
     
    MA123 10